Chronic ‘cough hypersensitivity syndrome’: A more precise label for chronic cough

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Chronic cough hypersensitivity syndrome

Chronic cough has been suggested to be due to three conditions, asthma, post nasal drip, and reflux disease. A different paradigm has evolved in which cough is viewed as the primary condition characterised by afferent neuronal hypersensitivity and different aspects of this syndrome are manifest in the different phenotypes of cough. There are several advantages to viewing cough hypersensitivity ...

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Cough hypersensitivity syndrome: towards a new approach to chronic cough.

Although cough is a highly frequent motive for visiting the doctor among both adults and children in primary care [1, 2], it usually resolves spontaneously within a few days or weeks. Conversely, chronic cough, broadly defined as cough persisting for more than 8 weeks, is often a more difficult clinical situation from both diagnostic and therapeutic perspectives [3]. In many patients, the anato...

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Chronic cough and obstructive sleep apnoea: reflux-associated cough hypersensitivity?

Obstructive sleep apnoea (OSA) is being increasingly recognised as a cause of chronic cough. The impact of continuous positive airway pressure (CPAP) therapy and the mechanism of this association are not well understood. We describe a patient with OSA and chronic cough who responded well to CPAP. Objective and subjective assessments of cough on treatment with CPAP, off CPAP and on follow-up as ...

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Chronic Cough 2 Management of chronic cough

Cough that remains unexplained after basic clinical assessment is a common reason for referral to secondary care. Much of the evidence about management of isolated chronic cough is derived from case series; this evidence suggests that isolated chronic cough is usually due to asthma, gastro-oesophageal refl ux disease, and upper airway conditions, and that it can be cured in most people by treat...

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Cough Hypersensitivity Syndrome: A Few More Steps Forward

Cough reflex is a vital protective mechanism against aspiration, but when dysregulated, it can become hypersensitive. In fact, chronic cough is a significant medical problem with a high degree of morbidity. Recently, a unifying paradigm of cough hypersensitivity syndrome has been proposed. It represents a clinical entity in which chronic cough is a major presenting problem, regardless of the un...

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ژورنال

عنوان ژورنال: Pulmonary Pharmacology & Therapeutics

سال: 2011

ISSN: 1094-5539

DOI: 10.1016/j.pupt.2011.01.012